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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE ESTIMATION OF SIMVASTATIN

Rupinder Kaur, Sukhdev Singh, Vandana Kharb, Upendra K. Jain, Mandeep Sharma*

ABSTRACT

A simple, rapid and economic UV method for the determination of simvastain in bulk and dosage form has been developed. The method proved linear in the range 1-20 μg ml-1 and exhibited good correlation coefficient (r2= 0.997). The method was also validated statistically for linearity, precision, repeatability, and reproducibility. The obtained result proved that method can be satisfactorily employed for the routine analysis of simvastatin.

Keywords: Validation, Spectrophotometry, Precision.


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