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Abstract

SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF 2-HYDROXY PHENYL THIAZOLIDINE-4-ONE DERIVATIVE

*S. Ramachandran, B. Bharathi, R. Lavanya, R. Nandhini, R. Sivaranjani, and Dr. R. Sundhararajan

ABSTRACT

A new series of N-(2-(2-hydroxyphenyl)-4-oxothiazolidin-3-yl) isonicotinamide derivatives were synthesized by the reaction of schiff base (Isoniazid and 2 hydroxy benzaldehyde) with mercaptoacetic acid respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. The synthesized compounds showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords: Antibacterial, Aromatic aldehyde, Isoniazid, Schiff Bases, Thiazolidine-4-one.


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