Photo Gallery



News & Updation

  • JULY 2018 Issue has been successfully launched on 1 July 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.



*S. E. Oriaifo, N. Oriaifo, J. Eigbefo, E. Okogbenin and C. Iruolagbe


Very recent findings indicate an important neuromodulatory role for astrocytes in altering neural circuit activity and behaviour. Artesunate, esomeprazole and furosemide are now verified agents that modulate noxious agents-induced hazardous orchestra via ATP- P2X7R-P2YI-NLRP3-A2AR signalling in astrocytes. Their mechanisms of action converge on down-regulating hyperglutamatergic excitotoxicity-and caspase-I-induced pyroptosis. They are therfore in a position to down-regulate inflammatory-related oxidative stress implicated in the mechanisms of chronic CNS diseases such as type 2 diabetes-induced complications, epilepsy and Alzheimer’s disease. Importantly, these agents, which also exhibit anti-malarial activities, may become significant alternatives to present AEDs which are associated with short-comings such as drug resistance, cognitive decline, oxidative stress and even metabolic syndrome. In the present study, the effect of intermittent low-dose artesunate + esomeprazole and furosemide sequential therapy was investigated for their anti-epileptic effects. In children, intermittent use of these agents over a period of 4 months significantly (P< 0.05) abrogated seizure recurrence in six patients with epilepsy and status epilepticus studied. Episodes of fever were also reduced in those who were placed on the sequential combination therapy. The drugs deserve careful attention in our locality where malaria, other infections and birth injuries have co-operated to maintain, at least, a sustained prevalence rate of epilepsy and related illnesses.

Keywords: Artesunate, Esomeprazole, Furosemide, Excitotoxicity, Seizures, Attenuation.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More