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Abstract

IN VITRO COMPARATIVE SYUDY OF QUALITY CONTROL PARAMETERS OF SOME BRAND OF KETOROLAC TABLETS AVAILABLE IN BANGLADESH

Syeda Afsana Nushrat, Waheeda Nasreen and Kanij Nahar Deepa*

ABSTRACT

Ketorolac is a non-steroidal agent with potent analgesic and moderate anti-inflammatory activity. It is administered as the tromethamine salt orally, intramuscularly, intravenously and as a topical ophthalmic solution. Six different sample brands marketed in Bangladesh were used to evaluate their comparative characteristics in different quality control parameters. The prime objective of the present study was to evaluate and compare the physicochemical parameters of different tablets of different brands that are available in local market of Bangladesh. General physicochemical parameters like thickness, diameter, weight variation, hardness, friability, disintegration time, dissolution were evaluated to ensure quality tests of tablets. All the brands complied with the official specification for friability, uniformity of weight and disintegration time. The safety and efficacy of drug was determined by means of content assay. Potency was determined by using UV method. The potency of ketorolac in six brands was within acceptable range (102.32±0.35%, 95.76±0.21%, 100.56±0.58%, 98.73±0.46%%, 104.29±0.90, 97.76±0.13%). All the brands showed better dissolution profile as they released more than 75% drug in 45 min. The study revealed that most of the marketed ketorolac tablets met the standards for physical properties which are the indicators of drug quality.

Keywords: ketorolac, physicochemical parameters, potency, dissolution profile.


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