Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF VALSARTAN

Sucharitha. M*, Anjali Devi.N, Vishnu Priya.P, Shyamala, JVC. Sharma

ABSTRACT

Valsartan, an angiotensin-receptor blocker (ARB) widely prescribed in variety of cardiac conditions like hypertension, diabetic nephropathy and heart failure. The biological half-life (3-6 hours) and maximum absorption in initial part of gastro intestinal tract of Valsartan favors development of gastro retentive floating dosage form. In the present study Valsartan floating tablets were prepared by effervescence method using sodium bicarbonate and citric acid as a gas generating agent. The tablets were formulated using direct compression technology by employing polymers like HPMC K4M, HPMC K15M, HPCM K 100M and Eudragit. The drug-excipient compatible studies were performed by FTIR, and the study revealed that there is no drugexcipient interaction. The prepared floating tablets were evaluated for various physicochemical parameters. The in-vitro drug release pattern of Valsartan floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with Higuchi mechanism. Out of all formulations the one prepared with Eudragit was optimized based on desired sustained release time (24hrs) followed by acceptable swelling and floating properties.

Keywords: Valsartan, Floating tablets, HPMC, Eudragit, direct compression, sustained release.