WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

DETERMINITAION OF BENZALDEHYDE GENOTOXIC IMPURITY IN LACOSAMIDE DRUG SUBSTANCES USING HPLC TECHNIQUE

Dr. Ritesh Kumar Srivastava*

ABSTRACT

Benzaldehyde has been highlighted as one of the potential genotoxic impurities (PGIs) in Lacosamide drug substances. A sensitive HPLC method was developed and validated for the determination of benzaldehyde in lacosamide drug substances. HPLC method on Kromasil C18 column (250 X 4.6 mm, 5μm), with UV detection at 250 nm was used. The proposed method was cost effective, specific, linear, accurate, rugged and precise. The calibration curves showed good linearity over the concentration range of 1.13 μg/g to 5.64 μg/g with respect to the sample and the correlation coefficient was 0.9981. Accuracy results were well in the range 96.28 to 101.41%. and method very sensitive.

Keywords: Impurity, HPLC, TTC, ICH guidelines, Validation.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More