Abstract

EFFECT OF SIZE REDUCTION AND DRYING TECHNOLOGY ON GRANULES PRODUCTION

Md. Rageeb Md. Usman*, Arun S. Mahajan and Sandip R. Pawar

ABSTRACT

Granulation is well known important unit operation in the Production of pharmaceutical solid oral dosage forms. Granulation process must be forwarded to improve from, compressibility of powder characteristic, improve the content uniformity, decreases isolation rate and avoided excessive fines practical. The result will be improve yields, reduction defects, increased productivity and reduce down time. The pharmaceutical Industry has employs several techniques like as direct compression, wet granulation, dry granulation methods for production of granules. The granules typically have a size rang between 0.2 to 0.4 mm bases on subseques several use. The aim of present work is focus on the factors affecting granulation like as size reduction and moisture contents. Also addition Information of drying technology and applicable use of granulation.

Keywords: Granulation, Techniques, factors, Application, Production.