Abstract

CLINICAL AND LABORATORY PROFILE IN SEROPOSITIVE DENGUE CASES AT A TERTIARY CARE HOSPITAL, SOUTH INDIA

Tabasum Begum M.*, Dr. M.N. Sumana and Dr. Basavana Gowdappa H.

ABSTRACT

Dengue is an acute febrile viral disease and is one of the most common arboviral mediated outbreaks reported with increased prevalence and with considerable morbidity and mortality. The present study aimed to analyze demographic, clinical and laboratory parameters of dengue cases which increases the sensitivity of screening by healthcare professionals in the most serious cases and to identify laboratory markers that may lead to the disease. A total of 258 cases suspected of dengue were reported from July 2014 to September 2014. Out of which 149 cases were serologically positive for dengue infection. Demographic profile, clinical manifestation and laboratory parameters were noted. Of 149 serologically positive cases, majority were males (62.41%). Fever was the major symptom (100%) followed by headache (95.9%), myalgia (92.6%), retroorbital pain (84.5%), rash (30.8%), abdominal pain (65.1%), pleural effusion (32.8%), petechiae (45.6%), epistaxis (30.8%) and ascites (8.05%). The most common haematological findings were thrombocytopenia, leucopenia. Biochemical parameters like aminotranferases were significantly raised. Serum sodium and potassium levels were below normal range and chlorides were significantly raised. Hence, a platelet count of <100,000 cells/μl, leucopenia of <4000cells/μl and aspartate aminotransferase levels of > 90 U/L, alanine aminotransferase levels of >90 U/L, serum sodium of <135 m Eq/L, serum potassium of <3.5 m Eq/L and serum chloride of > 106 m Eq/L can be considered as predictors of dengue infection.

Keywords: Dengue, Clinical manifestation, Laboratory parameters.