ANTIPYRETIC AND PURGATIVE ACTIVITIES OF CLITORIA TERNATEA LEAVES EXTRACTS
Murugalakshmi.M*, Valli.G, Mareeswari.P and Thangapandian.V
ABSTRACT
The Clitoria ternatea extracts were prepared from Clitoria ternatea
leaves in ethanol and acetone by Soxhlet Extraction using standard
procedure. Clitoria ternatea belongs to the family Papilionaceae,
commonly known as ‘Aparajita’ or ‘Girikarnika’. It is a perennial
climber widely used in the traditional Ayurvedic system of Indian
medicine for treating a variety of ailments. Antipyretic and purgative
activities of ethanol and acetone extracts were studied using albino rats
of both the sexes. Animals were divided into four groups each
consisting of six animals. Group 1 served as control, group 2 received
standard drug. Group 3 received 400 mg/kg of ethanol extract and
Group 4 received 400 mg/kg of acetone extracts of Clitoria ternetea.
For the determination of antipyretic activity, pyrexia was induced by 20% yeast
suspention.The purgative activity of both the extracts were also determined.The results
obtained showed that the extracts were found to exhibit antipyretic and purgative activities.
Present study highlights the significant antipyretic activity of the ethanol and acetone
extracts of Clitoria ternatea leaves. The antipyretic activity of Clitoria ternatea leaves extract
was found to be higher than the standard drug paracetamol. The purgative activity reveals
that the induction of purgation was significant for acetone extract. Ethanol extract of Clitoria
ternatea was found to exhibit higher degree of purgation than the standard sodium
picosulphate. The reduction in rectal temperature was found to be 0.550C than the standard
paracetamol (0.350C).
Keywords: C. ternatea, antipyretic, purgative, pyrexia, paraacetamol, sodium picosulphate.
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