Abstract

ANTI SEZURE ACTIVITYOF MUSSAENDA FRONDOSA EXTRACTS COBALT-INDUCED EPILEPTOGENIC CORTEX IN RATS

Sandhyarani Guggilla* and A. Ramesh

ABSTRACT

Objective: The present report is an investigation of anti seizure activity of Mussaenda frondosa in male Wistar albino rats by using Cobalt induced Epilepsy. Method: The MEMF at doses of 200 and 400mg/kg, p.o and the standard drug Silymarin (100mg/kg, p.o) were administered three times at 12h intervals and then Cobalt (1ml/kg) was administered to all the groups except normal control for 2 days. The antiseizure activity was assessed by using various biochemical parameters histopathological studies were observed after 36h of Cobalt treatment. Results and Discussion: The MEMF at the doses of 200 and 400mg/kg inhibited Cobalt induced brain toxicityin Wistar albino rats as assessed by the biochemical changes and histopathological studies. Conclusion: The methanolic extract of aerial parts of Mussaenda frondosaafforded significant protection against Cobalt-induced epileptogenic cortoxy injury.

Keywords: Mussaenda frondosa Brain toxicity, Sylimarine.