Abstract

HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF HIBISCUS SABDARIFFA ON ALCOHOL INDUCED HEPATOTOXITY IN RATS

Bhavana G.*, R. Rajani, Jeevan Mai Babu and Brahmaiah Bonthagarala

ABSTRACT

The aim of present study was to investigate the Hepatoprotective activity of aqueous extract of Hibiscus Sabdariffa leaves in female albino rats on alcohol induced hepatotoxic activity. The efficacy of any hepatoprotective drug is essentially dependent on its capability of either reducing the harmful effects or in maintaining the normal hepatic physiological mechanism. Orally administered doses of 200 and 400 mg/kg of aqueous extract of leaves of Hibiscus Sabdariffa produced significant decrease in AST, ALP, ALT levels and bilirubin. The activity of the extract is found to be dose dependent. The hepatoprotective effect of the drug was further supported by the histopathological examinations of the liver sections which reve1al that the normal liver shapes was distributed by hepatotoxic intoxication. In the liver sections of the rats treated with Hibiscus Sabdariffa extract and intoxicated with Alcohol the normal cellular shape was retained as compared to silymarin, thereby confirming the protective effect of the extracts of Hibiscus Sabdariffa. The hepatoprotective activity of Hibiscus sabdariffa could be due to the presence of bioflavonoids which have hepatoprotective properties. The result of this investigation indicated that the aqueous extract of Hibiscus Sabdariffa leaf possess hepatoprotective activity against alcohol induced liver damage in rats.

Keywords: Hepatoprotective activity, Alcohol Induced Hepatotoxic activity, Hibiscus Sabdariffa, ANOVA, ALT, AST, AEHS, SGPT, SGOT.