Photo Gallery



News & Updation

  • JUNE 2018 Issue has been successfully launched on 1 June 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.



Sanjib Kumar Yadav* and Dr. Nagrathna P.K.M.


Objective: The aim of the current study was to evaluate the cardioprotective effect of the methanolic extract of Terminalia coriacea on doxorubicin induced cardiotoxicity. Methodology: For cardiotoxicity, thirty rats were evenly divided into 5 groups. Groups-1 served as controls, Group-2 standard drug treated group, Group-3 vitamin-E treated group, Group-4 test drug(low dose) treated group, Group-5 test drug(high dose) treated group and treatment is given for 7 days, On 8th and 9th day need to induce cardiotoxicity with doxorubicin, then on 10th day need to sacrifies rat then blood samples is taken for lipid profile test and the rat heart and liver for histopathology were obtained under inhaled diethyl ether anesthesia. Result: administration of doxorubicin in control rats showed a significant increase serum total cholesterol(TC), triglycerides(TG), lowdensity lipoprotein(LDL) and decrease in high density lipoprotein (HDL). Rats treated with hydromethanolic extract of Terminalia coriacea (200 mg/kg and 100 mg/kg) showed decreased TC,TG,LDL and increases HDL levels. The histopathological studies also showed that the plant extract significantly minimized the damage induced by doxorubicin. Conclusion: thus, Terminalia coriacea provide cardioprotection against doxorubicin induced MI in rates.

Keywords: cardiotoxicity, Terminalia coriacea, doxorubicin, MI, propranolol, vit-E and Albino rats.

[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More