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  • JUNE 2018 Issue has been successfully launched on 1 June 2018

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Nikhil P. Mahalpure*, Sheetal B. Gondkar, Shalaka P. Rasal and
Ravindra B. Saudagar


The major objective of this study was to develop controlled porosity osmotic pump tablets of linagliptin to be taken once daily. Unlike the elementary osmotic pump which consists of an osmotic core with the drug surrounded by a semi permeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of channeling agent in the coat. NaCl was used as an osmogent and HPMC K100M was used as a release retardant. Cellulose acetate was used as the semipermeable membrane and PEG 400 was used as pore forming agent. Optimization was done using 32 factorial design considering two independent variable at three levels. Optimized formulation exhibited zero order kinetics with a drug release of 98.43% in 24 hrs. Scanning electron microscope studies showed the formation of pores in membrane (Coat). It was concluded that release of linagliptin was significantly controlled from controlled porosity osmotic drug delivery systems.

Keywords: Controlled porosity osmotic pump (CPOP), Linagliptin, Osmogent, Pore former.

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