Photo Gallery

Login

Search

News & Updation

  • WJPPS JUNE ISSUE PUBLISHED
  • JUNE 2017 Issue has been successfully launched on 1 June 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

DEVELOPMENT OF CONTROLLED POROSITY OSMOTIC PUMP TABLET OF LINAGLIPTIN

Nikhil P. Mahalpure*, Sheetal B. Gondkar, Shalaka P. Rasal and
Ravindra B. Saudagar

ABSTRACT

The major objective of this study was to develop controlled porosity osmotic pump tablets of linagliptin to be taken once daily. Unlike the elementary osmotic pump which consists of an osmotic core with the drug surrounded by a semi permeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of channeling agent in the coat. NaCl was used as an osmogent and HPMC K100M was used as a release retardant. Cellulose acetate was used as the semipermeable membrane and PEG 400 was used as pore forming agent. Optimization was done using 32 factorial design considering two independent variable at three levels. Optimized formulation exhibited zero order kinetics with a drug release of 98.43% in 24 hrs. Scanning electron microscope studies showed the formation of pores in membrane (Coat). It was concluded that release of linagliptin was significantly controlled from controlled porosity osmotic drug delivery systems.

Keywords: Controlled porosity osmotic pump (CPOP), Linagliptin, Osmogent, Pore former.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More