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Abstract

METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL, IBUPROFEN AND CHLORZOXAZONE IN BULK AND COMBINED TABLETS DOSAGE FORMS

Dnyanda Dalvi* and Dr. Snehalatha Boddu

ABSTRACT

This method describes a procedure to quantify the assay of Paracetmol, Ibuprofen and chlorzoxazone tablet using a mobile phase containing mixture of acetonitrile: 0.02M potassium dihydrogen phosphate buffer (60:40) adjusted to PH 3with Orthophosphoric acid, at flow rate 1ml/min in isocratic mode. The detector was set at 221nm. Paracetamol, Chlorzoxazone and ibuprofen is subsequently analyzed by reverse phased HPLC Prontosil C18 column (250 x 4.6mm, 5μm). The retention time of Paracetamol, Chlorzoxazone and Ibuprofen peaks are about 2.263, 3.773 and 8.897minutes respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity and robustness. The linearity for Paracetamol, Chlorzoxazoneand Ibuprofen was in the range of 39-104μg/mL, 30-80 μg/ml and 40-140μg/ml respectively. The method was successfully applied to the estimation of paracetamol ibuprofen and chlorzoxazone in combined dosage form.

Keywords: Paracetamol, Chlorzoxazone, Ibuprofen, Validation, RP-HPLC.


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