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Abstract

EVALUATION OF DICLOFENAC SODIUM TABLETS FORMULATED WITH CO – PROCESSED ACACIA-SIDA ACUTA GUM

Dr. Okafo Sinodukoo Eziuzo* and Prof, Dr. Chukwu Amarauche

ABSTRACT

The present study investigates the effect co-processing of Acacia gum with Sida acuta gum has on the drug release profile of diclofenac sodium tablets. Acacia gum powder was co-processed by physical admixture with Sida acuta gum powder in the ratio of 2:1 (F2) and 1:1 (F3) and also by co-precipitation with isopropyl alcohol of the mucilage formed from the physical admixtures respectively (F4 and F5). The co-processed excipients were characterized for solubility, angle of repose, true, bulk and tapped densities. Five batches of diclofenac sodium granules were formed using acacia alone (F1) and the four co processed excipients (F2 – F5) as 5%w/w binders respectively. The granules were evaluated for average particle size, angle of repose, bulk and tapped densities. The granules were compressed into tablets and evaluated for their disintegration time, % drug release profile, friability and hardness. The hardness value for batches F1 to F5 tablets were 6.099±2.609, 6.74±0. 565, 6.981±1.896, 7.046±2.487 and 5. 545±1.978 respectively. The mean disintegration time ± S.D for batches F1 to F5 ranged from 6.33±0.58 to 14.00±1.00 min. The % drug release for batches FI to F5 at 10 min time interval were 89, 48, 59, 65 and 50 % , at 20 min, were 100, 62, 61, 70 and 56 %, and at 60 min were, 100, 100, 72, 100 and 71 % respectively. Acacia gum co-processed with Sida acuta could be used to effect drug release retardation and this increases with increase Sida acuta gum ratio.

Keywords: Co-processing, acacia, Sida acuta gum, co-precititation, diclofenac sodium.


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