Photo Gallery

Login

Search

News & Updation

  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2017 Issue has been successfully launched on 1 October 2017

  • ICV
  • WJPPS Rank with Index Copernicus Value 52.51 due to high reputation at International Level

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.041 to 6.647 due to high quality Publication at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI-HYPERGLYCEMIC EVALUATION OF NEW METFORMIN DERIVATIVES

Yasir K. Mahdi*

ABSTRACT

Metformin is a cornerstone in the treatment of type 2 diabetes particularly in obese patients. Its main actions are the suppression of gluconeogenesis and the improvement of glucose uptake and insulin sensitivity. A series of metformin derivatives (III a-b) have been synthesized by reaction of metformin, chloroacetyl chloride and an appropriate phenol. The chemical structure of the intermediates and the final compounds were confirmed by measuring their melting points, FT-IR spectroscopy and HNMR spectroscopy of the final compounds. All the new compounds were evaluated for their anti-diabetic activity using streptozotocin induced diabetic rats model. Fasting blood glucose level was estimated on hours 0,2,5,6 and 24 from rat tail vein using glucometer. The newly synthesized compounds showed significant anti-hyperglycemic activity compared to metformin.

Keywords: metformin, anti-hyperglycemic activity, phenols, streptozotocin.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More