WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF CLOTRIMAZOLE, FUSIDIC ACID AND MOMETASONE FUROATE IN CREAM BY RP-HPLC.

Devanshi G. Trivedi*, Ankit B. Chaudhary and Bhoomi D. Patel

ABSTRACT

The present work describes a validated reverse phase high performance liquid chromatographic method for estimation of Clotrimazole, Fusidic acid and Mometasone furoate in cream formulation. Chromatography was performed on a Hypersil ODS C18 column (250 × 4.6 mm, 5μm particle size) column with mobile phase containing 0.05M Potassium dihydrogen phosphate (pH 6.0 ± 1 % using Sodium Hydroxide): Acetonitrile (60:40). The flow rate was 0.8 ml/min and the eluent was monitored at 230 nm. The selected chromatographic conditions were found to effectively separate Clotrimazole (Rt- 4.277 min), Fusidic acid (Rt- 3.103 min) and Mometasone furoate (Rt- 5.707). Linearity for Clotrimazole, Fusidic acid and Mometasone furoate were found in the range of 10-30 μg/ml and 20-60 μg/ml and 1-3 μg/ml respectively. The proposed method was found to be fast, accurate, precise and reproducible and can be used for estimation of these drugs in cream.

Keywords: Clotrimazole, Fusidic acid, Clotrimazole, RP-HPLC, Estimation.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More