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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG ALBENDAZOLE BY SOLID DISPERSION TECHANIQUE

Harshada Patil*, Sulbha Patil and Dr. Sunil Pawar

ABSTRACT

This research work investigates enhancement of the solubility of albendazole by solid dispersion technique. A phase solubility study was used to evaluate the effect of various soluble polymers on aqueous solubility of Albendazole.The polymers used were Polyethylene glycol (PEG 6000), Hydroxy propyl methyl cellulose (HPMC E4) and solid dispersions were prepared by hot melt method and Kneding method. The prepared solid dispersions were characterized by Fourier transform spectroscopy (FTIR), to identify the physicochemical interaction between drug and polymers. The dissolution studies of solid dispersion were performed by using USP II apparatus (paddle type). Albendazole is a Anthelmintic drugnresistance has led to alternatives in controlling helminth infections.

Keywords: Solid dispersion, Albendazolel, HPMC E4, PEG6000 and Solubility enhancement.

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