Abstract

ETODOLAC LOADED ETHOSOMES: DESIGN AND IN VITRO CHARACTERIZATION

M. D. Safeeruddin*, J. Hindu Manognya, P. Sravani, Dr. K. Rajeshwardutt, B. Shruthi and G. Ravali

ABSTRACT

The present work deals with the preparation of Etodolac ethosomes and study of effect of alcohol and phospholipid on transdermal delivery. Etodolac is a nonsteroidal anti-inflammatory drug used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the cyclooxygenase (COX) enzymes which form prostanoids, resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.Skin is the main target of topical and transdermal preparations. Major aim of transdermal drug delivery system is to cross stratum corneum. Ethosomal carriers are system containing soft vesicles, composed of hydro alcoholic or hydro/glycolic phospholipid in which the concentration of alcohol is relatively high. Etodolac loaded ethosomes were prepared by hot method by using different concentrations of Alcohol and phospholipids in different ratios and propylene glycol. The prepared ethosomal formulations were evaluated for Vesicle size analysis, Morphological studies, Entrapment efficiency, In vitro release, Stability studies, In vitro permeation study.

Keywords: Etodolac ethosomes, Inflammation, Transdermal Drug Delivery, Method of preparation.