Abstract

TARGETED DRUG DELIVERY- A REVIEW

E.Bhargav*, N.Madhuri, K.Ramesh, Anand manne, V.Ravi

ABSTRACT

At present 95 percent of all new potential therapeutics have poor pharmacokinetic and biopharmaceutical properties. Hence there is need to develop a suitable drug system that distributes the therapeutically active drug molecule only to site of action, without affecting healthy tissue or organ. Among drug carrier soluble polymers, microparticles made of insoluble (or) biodegradable natural and synthetic polymers, microcapsules, cells, cell ghosts, neutrophils, fibroblasts, artificial cells, lipoproteins, lipososmes and micelles, immune micelle, monoclonal antibodies can be taken into consideration. Liposomes are micro particulate lipoidal vesicles which are under extent of therapeutic investigation as drug carriers for improving the delivery of therapeutic agents. Most clinical applications of liposomal drug delivery are targeting to tissue with or without expression of target recognition molecules on lipid membrane. Microspheric drug delivery system has gained enormous attention due to its wide range of application as it covers targeting the drug to particular site to imaging and helping the diagnostic features. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials. Monoclonal antibody technique involves fusing a normal antibody producing B cell with a myeloma cell to produce a hybrid cell or hybridoma they are excellent candidates as carriers of therapeutic agents for delivery to specific sites. This paper explores various aspects of nanoparticles, microsphere, liposomes and monoclonal antibodies formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules.

Keywords: Targeted drug delivery, Microspheres, Nanoparticles, Liposomes, Monoclonal antibodies.