Abstract

STRUCTURAL AND MECHANICAL ANALYSIS OF POLYMER STRUCTURAL COMPOSITION OF MATRIX TRANSDERMIC THERAPEUTIC SYSTEM WITH THIAMAZOLE

Ratushnyi Sergii Volodymyrovych, Butska Victoria Yevgenivna, Shiteeva Tetiana Oleksiivna

ABSTRACT

That is the main purpose of this article is evaluation of structural and mechanical properties of polymer matrix for creations of transdermal therapeutic system with thiamazole. The structural-mechanical analysis of prospective polymer structural composition of matrix transdermic therapeutic system was conducted. It was proved that according to its elastic-plastic-viscosity properties polymer structural composition refers to the first structural-mechanical type. And insertion of plasticizers and solvents significantly influences the physical and chemical mechanics of polymer structural composition, transferring it from the first to zero structural-mechanical type.

Keywords: transdermal therapeutic system, thiamazole, mechanical structural analysis, polymer composition, polyvinylpyrrolidone.