Abstract

STUDYING THE ENZYMES LEVELS IN CEREBROSPINAL FLUID FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Luay Abed Al-Helaly, Sayran Sattar Saleh and *Lelas Farhan Bdaiwi

ABSTRACT

The research includes studying of enzymes levels in the cerebrospinal fluid (CSF) for children with acute lymphoblastic leukemia (ALL) by determination of (9) parameter which include biochemical parameters: Acetylcholinesterase (AChE), Pseudocholinesterase (PChE), Monoamine oxidase A (MAOA), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), Creatinine kinase (CK), Lactate dehydrogenase (LDH) and Superoxide dismutase (SOD). The study was done on (140) sample had acute lymphoblastic leukemia (95) were male and (45) female, beside of (73) were healthy children as control group which include (39) male and (34) female the age of children with acute lymphoblastic leukemia ranged from 1-15 year for both sex. The results showed there was a significant decrease in the activity of AChE, PChE and a significant increase in MAOA, AST, ALT, ALP, CK, LDH and SOD in CSF for children with acute lymphoblastic leukemia patients compared with control group for both sexes and these were a very good biochemical indicators for the patient body biochemical functions. The blood brain barrier loss its function in maintaining brain homoeostasis because of the oxidative stress and the age group (11-15)y of male had higher oxidative stress.

Keywords: Acute lymphoblastic leukemia, Cerebrospinal fluid, Enzymes.