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Abstract

CARRAGEENAN AS RELEASE CONTROLLING POLYMER IN INSOLUBLE ANTI-PSYCHOTIC DRUG MATRIX

*Himankar Baishya, Libin and Wang

ABSTRACT

This study investigates the potential of three commercial carrageenans, Gelcarin GP379, Gelcarin GP911, Gelcarin GP812 (Iota-carrageenan) and Viscarin GP209, Viscarin GP109 (lambda-carrageenan) & Seaspen to be used for the preparation of controlled-release tablet matrices. Properties of all six categories of Carrageenan were discussed (Table -1). During formulation of Oral Dosage, wet granulation process was adopted considering the flow property of selected raw material. In different stages of manufacturing the critical parameters such as Impact of Carrageenan on particle size distribution, tablet hardness & drug release profiles etc. were studied.

Keywords: Carrageenans, Particle size Distribution, Drug release profile.


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