Abstract

ISOLATION OF PECTIN FROM ORANGE PEEL AND ITS USE AS BINDER IN THE TABLET FORMULATION

Swati Chavan*, Suvarna Dhangar, Sandhya Borse, Vipul Jain, Laxmikant Borse, Sunil Pawar

ABSTRACT

An orange is the most commonly grown tree fruit in the world. The orange peel is the waste part of orange which remains after squeezing and is the potential source of pectin. The powder obtained from orange peel was subjected to decoction with water and pectin was isolated with ethanol. Pectin was confirmed by identification tests. The placebo tablets were formulated using pectin as a binder in different proportions (10, 20, 30, 40 mg). Pre-compression and post-compression evaluation studies were performed for all the formulated tablets and were found to be within the range as referred in the pharmacopoeias. Friability, hardness and disintegration time of formulation F3 (30mg of pectin) showed better results as compared to the other formulation. As the evaluation tests showed weight variation, friability, hardness, disintegration time of formulation within the range, the pectin isolated from orange peel can serve as an excellent binder in the tablet.

Keywords: Orange peel, pectin, binding properties, ethanol, binder, placebo tablet.