Abstract

BIOSYNTHESIS OF SILVER NANOPARTICLES FROM AQUEOUS EXTRACT OF BAUHINIA ACUMINATA USING VARIOUS PHYSICAL PARAMETERS AND ITS APPLICATIONS

Divya Sebastian* and Albin T. Fleming

ABSTRACT

Bauhinia acuminata, from southwestern region of Kerala medicinally important in traditional system of medicine and are used as an effective natural drug. To synthesize silver nanoparticle from Bauhinia acuminata aqueous leaf extract obtained by changing different reaction parameters such as temperature, reaction time, varying ratio and concentration of plant extract and precursor (AgNO3). The characterization of Bauhinia acuminata silver nanoparticle using UV-Vis spec. Now days microbial resistance to antibiotics is a serious concern in medicine. The use of silver nanoparticles (AgNPs) as a potent antibacterial agent has received much attention. BAAgNPs have multiple targets and found to be effective against C. freundi and M. luteus was found to be <1000 and 750 μg using MIC assay. The molecular docking affinity of Phytol ligand binding to cellular receptors like 5DZL with -2.53 kcal/mol shows the effective nature of the aqueous leaf extract components. The BaAgNPs shows the effective antimicrobial inhibition against E.coli and S.aureus.

Keywords: BaAgNPs, UV-Vis spec, MIC, Molecular Docking.