Abstract

HEPATOPROTECTIVE ACTIVITY OF LIGNAN COMPOUND FROM FLAXSEED (Linumusitatissimum L.) AGAINST ACETAMINOPHENINDUCED HEPATOTOXICITY IN RABBITS

*Essam F. Al-Jumaily and Ahmed H. AL-Azawi

ABSTRACT

The hepato-nephroprotective effect of the flaxseed lignan was evaluated in paracetamol-induced hepato-nephrotoxicity in rabbits. Biochemical studies show that there is an significantly increased (p <0.05) in the levels of serum ALP, ALT, AST, Bilirubin, blood urea and creatinine with decrease in the levels of total protein and albumin in paracetamol treated group compared to the control group. These values are retrieved significantly by treatment with lignan extracts at two different doses (25 and 50 mg/ml). From the results can be concluded that the compounds pure and partial pure lignan can prevent liver and renal damage from paracetamol induced hepatonephrotoxicity in rabbits. Therefore the potential use of flaxseed lignan as a therapeutically useful hepato-nephroprotective agent.

Keywords: Lignan, flaxseed, paracetamol, induced hepatonephroprotective.