Abstract

DEVELPOMENT OF NOVEL NANOPARTICULATE DRUG DELIVERY SYSTEM OF RIFABUTIN

Kumari Mamta*, Dr. Agrawal Amit, Mishra T. S., Kumari Manisha and
Bhawarker Swati

ABSTRACT

Nanotechnology has the potential to offer solutions to these current obstacles in cancer therapies, because of its unique size and large surface-to-volume ratios. Nanoparticles may have properties of self-assembly, stability, specificity, drug encapsulation and biocompatibility as a result of their material composition. The multidisciplinary field of nanotechnology’s application for discovering new molecules and manipulating those available naturally could be excited in its potential to improve health care. Nanotechnology is definitely a medical boon for diagnosis, treatment and prevention of various diseases including cancer. It supports and ex-pands the scientific advances in genomic and proteomics and builds on our understanding of the molecular under-pinnings of cancer and its treatment. Encapsulation of rifabutin in Gelatin nanoparticles enables development of the intravenous formulation of this poorly soluble anti-tuberculosis antibiotic. After oral administration, the nanoparticle-based formulation of rifabut in produced a 2-fold increase in bioavailability, as compared to the parent drug the present study work on Development of Novel Nanoparticulate Drug Delivery System of Rifabutin.

Keywords: Nanotechnology, Rifabutin, HPLC, methanol, Solubility, UV.