Abstract

EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC POTENTIAL OF PETROLEUM ETHER EXTRACTS OF MALVASTRUM TRICUSPIDATUM STEM BARK ON ALBINO MICE

R. Kumar*, A. Upadhyay, K. Kaushik, J. Khan, S. S. Saurabh, G. Jeyabalan

ABSTRACT

In the present study, stem bark of plant Malvastrum tricuspidatum were selected for preliminary phytochemical investigation and pharmacological evaluation for analgesic & anti-inflammatory activity. Extraction of stem bark of M. tricuspidatum was carried out by defatting powder with petroleum ether followed by extraction with ethanol. As a model of inflammation, carrageenan induced mice paw edema, dextran induced mice paw edema, histamine induced mice paw edema, formalin induced paw edema and cotton pellet induced granuloma in rats were utilized in the present study. In conclusion, the studies have shown that the petroleum ether extract of Malvastrum tricuspidatum contains some active ingredients with the potential of being good anti-inflammatory and analgesic agents. The results of the study were subjected to one way analysis of variance followed by student t-test for multiple comparisons. Values with P < 0.05 were considered significant.

Keywords: Analgesic activity, Anti-inflammatory activity, pharmacological evaluation.