Abstract

RESEALLED ERYTHROCYTES: A BIOCARRIAR FOR DRUG DELIVERY

Dharmendra Solanki*, Pragya Sharma, Mohit Motiwale and Lalit Kushwah

ABSTRACT

Red blood cells are the most common type of blood cells. RBCs have shapes like biconcave discs with a diameter of 7.8 μm and thickness near 2.2 μm. Erythrocytes can be used as carriers in two ways: targeting particular tissue/organ, for continuous or prolonged release of drugs. Various types of mammalian erythrocytes have been used for drug delivery. Various methods are hypo osmotic method, dilution method, dialysis method, press well method, isotonic osmotic lyses, electrical break down method, endocytosis method, membrane perturbation method, normal transport method and lipid fusion method. After loading of therapeutic agent on erythrocytes, the carrier cells are exposed to physical, cellular as well as biological evaluations. Carrier RBCs have proved to be useful for a variety of in vitro tests. The most frequent in vitro application of RBC mediated micro injection. Now a day’s there are numerous applications have been proposed for the use of resealed erythrocytes as carrier for drugs, enzyme replacement therapy etc.

Keywords: RBCs, Erythrocytes, Resealed Erythrocytes, Biocarriar.