Abstract

ABSTRACT SOME ADVERSE EFFECTS OF TIAMULIN IN NORMAL AND MYCOPLASMA GALLISEPTICUM INFECTED CHICKEN

Mossad G.A*, Enas A.H. Farag and Mai Gamal

ABSTRACT

This study was conducted on 200 one day old chick which were divided into 4 groups. Group (1): Fifty chicks were served as non infected non treated group which administered saline only. Group (2): Fifty chicks of 25 days age were infected with isolate of Mycoplasma gallisepticum and served as infected non treated group. Group (3): Fifty chicks of 25 days age were non infected and treated with tiamulin (25 mg/kg B.Wt. orally for 5 days). Group (4): Fifty chicks of 25 days age were infected with isolate of Mycoplasma gallisepticum and administered (25mg/kg B.Wt. orally for 5 days). Blood samples were taken at the end of zero day(20 days age), 10th day and 15th post- treatment in all groups. Blood samples were taken from each group for biochemical studies. The treated chicks were sacrificed at zero, 10 days and 15 days post treatment. The effect of tiamulin (25 mg /kg body weight orally for five successive days) on biochemical parameters of healthy and experimentally infected chickens with Mycoplasama gallisepticum showed a significant increase in serum total bilirubin, direct bilirubin, indirect bilirubin, AST, ALT, ALP, total protein and albumin, a significant decrease in uric acid and creatinine and return to its normal level at 15 days post treatment.

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