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Abstract

A NEW ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATIONOF LEVOSULPIRIDE INBULK AND PHARMACEUTICAL TABLET DOSAGE FORMS BY UV SPECTROPHOTOMETRY

Vijayamma G.*, Venkatesh P., Hepcy Kala Rani D. and Ravindra Reddy K.

ABSTRACT

Objective: There is no analytical method yet reported for estimation of Levosulpiride using ethanolic water (1:9) ratio as a solvent either in single dosage form or in combination by UV spectroscopy. So, the present work is aimed to develop a simple, precise, accurate and new spectrophotometric method in UV- region for the estimation of Levosulpiride in its tablet dosage form. Levosulpiride exhibited maximum absorbance at 291.4 nm in ethanolic water (1:9). It obeys Beer’s law in the concentration range of 40-100μg /ml. Method: The quantitative analysis of Levosulpiride was carried out by single component analytical method by UV Spectrophotometry. bsorbance values of sample solution were recorded at 291.4nm. The estimation of the drug was carried out by regression equations with the standard solution. Results: The calibration graph was found to be linear with r2 0.999 at a range of concentration 40-100μg/ml. The relative standard deviation was found to be ≤0.055%, with repeatability values of range 100.6% ‐101.94% and recovery study values of range 110.1% - 131.3% were found. Conclusion: The proposed method of analysis of Levosulpiride is novel, simple, accurate and reproducible. This method can be routinely employed in the analysis of Levosulpiride in tablet formulations precluding using ethanolic water (1:9) ratio as a solvent.

Keywords: Levosulpiride, Analytical Method Development, Validation, UVSpectrophotometry.


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