Abstract

EVALUATION OF SYNERGISTIC EFFECT OF ORAL FORMULATION AND TOPICAL APPLICATION OF AYURVEDIC FORMULATION FOR ANTI ACNE EFFECT

Dr. Tanuja Nesari, Dr. Apoorva Sangoram*, Vd. Pooja Pawar, Vd. Smita Atkalikar, Vd. Trupti Nikam

ABSTRACT

Acne vulgaris can be correlated to Mukhdushika in Ayurveda is the most common skin condition found in second & third decade of life. The management includes Shodhan (Biopurification of Dosha), Shaman (Pacification of Dosha) & Topical application. The formulations for topical application and internal medication (Shodhan & Shaman) were developed for the present study with the aim to evaluate synergistic effect of these formulations, for Anti Acne effect. The herbs selected in the formulations were authenticated and standardized according to API guidelines. A prospective, randomized, open labeled, parallel study was designed. 75 patients with acne vulgaris were randomized into 3 groups: group A received oral formulation, group B received topical application and group C received combined treatment i.e. oral formulation & topical application for 60 days with dose for Shodhan – 3gm (H.S- after meal), Shaman – 1 gm (BD- after meals) and topical application - as required (H.S.). The outcome measurements were examined using 1.Ayurvedic parameters -symptom rating scale for Kandu (Itching), Vedana (pain), Vaivarnya (discolouration) and shotha (Inflammation) and 2. Conventional parameters- Global acne grading system, Indian authors grade Acne vulgaris and photographic evaluation. The results are highly significant at 5% level of significance (p < 0.05). Conclusion – Combined treatment of Shodhan and Shaman medicine along with topical application has synergistic effect was observed in group C.

Keywords: Acne vulgaris, Shaman, Shodhan, topical application, synergistic effect.