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Abstract

FTIR SPECTROSCOPIC METHOD FOR THE QUANTITATIVE ANALYSIS OF TOPIRAMATE IN TABLETS

*P.G. Sunitha, N. Deattu and R. Narayane

ABSTRACT

A rapid FTIR spectroscopic method has been proposed for the estimation of Topiramate in bulk drug and its pharmaceutical dosage form. The method involves the measurement of the area of the infrared band corresponding to the S=O stretching centered at 1049 cm-1. The excipients in the commercial tablet preparation did not interfere with the assay. The linearity range was found to be 100-600 μg /ml. The technique is reliable and useful for quality control for monitoring the adulteration of pure drug. The proposed method is statistically validated and found to be useful for the routine determination of topiramate in tablets.

Keywords: Topiramate, FTIR, Tablets, Validation.


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