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Abstract

FORMULATION AND CHARACTERIZATION OF IN-SITU GEL OF ONDANSETRON HYDROCHLORIDE DIHYDRATE

Dhobale Shankar*, Shelke Gajanan, Jadhav Suresh, Gaikwad Dushyant

ABSTRACT

The present investigation deals with the formulation, optimization and evaluation of sodium alginate based floating oral In situ gel of Ondansetron hydrochloride dihydrate (OHD). Sodium alginate and calcium carbonate used as a polymer and cross-linking agent respectively. Used Polymers exhibit sol-to-gel phase transition due to change in specific physicochemical parameters. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultraviolet irradiation from which drug gets released in sustained and controlled manner. Prepared In-situ gels assure that the formulation containing 2 % of sodium alginate control the release of drug for longer duration. The formulated in situ gel for OHD was found to be stable in-situ gel. It was found to have better floating efficacy and in vitro release profile characteristics. Better efficiency and results of batch F-6 gives newer alternative use of natural biodegradable polymers in situ gel formulation.

Keywords: Oral In-situ gel, Sustained Release, Sodium alginate, Calcium Carbonate, Ondansetron hydrochloride dihydrate (OHD).


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