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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF HEXAMETHYLENETETRAMINE COPPER (II) COMPLEX

Berhanu Degagsa, Gezahegn Faye*, Nester Fernandez

ABSTRACT

The complex, [Cu(C6H12N4)3(H2O)3]SO4, has been synthesized in a mixed solvent of water and ethanol. It has been characterized by Infrared and Electronic Spectra, Magnetic Susceptibility, Melting Point and Conductivity measurement. Quantitatively, Copper ion, Sulphate ion and HMTA in the complex were determined with the help of Flame Atomic Absorption Spectroscopy, Gravimetric and Volumetric Analysis respectively. The study results suggested distorted octahedral complex in which the central metal ion, Cu (II), is bonded to three water and three HMTA ligands. The ligand, HMTA, is active against Pseudomonas aeruginosa and Salmonella typhi while it is inactive against Staphylococcus aureus and Escherichia coli. But, the complex is active against all the four tested bacteria species. Specially, the complex showed greater activity than the reference antibiotic, gentamycin, against Staphylococcus aureus and Salmonella typhi.

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