Abstract

INSULIN MIMETIC AND PANCREAS-PROTECTIVE EFFECT OF TECOMELLA UNDULATA LEAVES EXTRACT IN DIABETIC RATS

Kanwar Lal, Ashok Purohit and Heera Ram*

ABSTRACT

The Great Indian Thar Desert having peculiar kind of flora which are using by local people in amelioration of various ailments and health prospective based on conventional wisdom. This study was assigned to evaluate Insulin mimetic and pancreas-protective efficacy of Tecomella undulata leaves extract in diabetic rats. The assigned objectives were evaluated by four experimental groups including treatments of 250mg/kg and 500mg/kg body weight for 28days. The adult albino rats were used for diabetic animal model having weight of 150 to 250gm. The diabetes was induced in overnight fasted animals by a single intraperitoneal injection of 60 mg/kg streptozotocin (STZ). The dose of leave extract of Ticomella undulata was administered orally at 250mg/kg and 500 mg/kg body weight of animal model for 28 days. The treatments of leaves extracts were significantly reduced sugar levels in gradual manners by different degrees at 7days, 14 days, 21days and 28 days. Supportive reductions were also shown through treatments in lipid profiles (Total cholesterol, LDL-cholesterol, VLDL – cholesterol and triglyceride). Correspondingly, body and organs weights were significantly altered after completion of experiment. Subsequently, histopathology of pancreas was shown improvements in histo-architectures of diabetic animal models. The pancreatic islet cells were shown normalcy in cellular status by treatments of leave extracts of Ticomella undulata as well as nuclear shape and morphology. Whereas, toxicity profile i.e. renal and hepatic function parameters were remained under and around normal ranges. Therefore, it is concluded that leave extract of Ticomella undulata possessing potential phytocompounds having insulin mimic and pancreas-protective efficacy.

Keywords: Diabetes, Insulin mimetic, pancreas-protective, histo-pathology, glucose levels, Ticomella undulata leaves extract.