WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

BENEFICIAL EFFECT OF CAPSAICIN ON ACUTE DOXORUBICIN INDUCED CARDIOTOXICITY IN MICE: POSSIBLE ROLE OF OXIDATIVE STRESS

Mihir K. Patel and Anita A. Mehta*

ABSTRACT

Doxorubicin has been widely used in various cancers including leukemia, sarcoma and breast cancers. Despite its clinical efficacy in wide range of cancers, its utilization has becoming a limited due to cardiotoxicity, which has been mainly associated with oxidative stress and apoptosis of heart tissue and resulting in Heart failure. Capsaicin being a pungent ingredient from hot chili pepper has been remaining an immense area of research for its beneficial antioxidant activity and shown to reduced oxidative stress. The current investigation aims to target the effect of capsaicin against DXR-induced cardiotoxicity in mice using biochemical and histopathological approaches. Capsaicin (1mg/kg/day and 2mg/kg/day) was administered intraperitoneally (i.p.) for 10 days and on day 8 DXR (20mg/kg, i.p.) was injected. After 72 h of administration of DXR i.e on day 11 study was terminated. Mice treated with DXR exhibited cardiotoxicity which was confirmed by elevation of serum CK-MB and LDH, tissue malondialdehyde (MDA) and decreased level of antioxidants enzymes (SOD, CAT and GSH). Treatment with capsaicin (1mg/kg, i.p.) exhibited significant improvement in CK-MB, LDH, MDA and total antioxidant enzymes levels. Histopathological examination revealed that cardiac damage with DXR was reversed with capsaicin + DXR treatment. These results suggest that capsaicin treatment involves cardioprotection against acute doxorubicin-induced cardiotoxicity in mice and this effect may be because of antioxidant potential of capsaicin.

Keywords: cardiotoxicity, Histopathological, malondialdehyde, Capsaicin, Doxorubicin, TRPV1 channel.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More