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Abstract

STABLITY-INDICATING SIMULTANEOUS ESTIMATION OF METOPROLOL AND CILNIDIPINE BY USING RP-HPLC

K. China Prasad*, M. Rama Krishna, D. Jeevanmani Babu, N. Anil Kumar and G. Raveendra Babu

ABSTRACT

In this study is stability-indicating simultaneous estimation of Metoprolol and Cilnidipine by using reversed phase high performance liquid chromatography. Optimization conditions was found to be phosphate buffer : acetonitrile in (60:40, v/v) ratio as mobile phase at a flow rate of 1.0 mL/min. The peaks were well resolved with BDS column (150 mm x 4.6 mm, 5 μm) with a retention times 2.679 and 4.026 min for Metoprolol and Cilnidipine respectively. UV detection was performed at 237 nm. The responses were linear (R2 > 0.9999) in the range of 12.5-75 μg/ml for Metoprolol and 5.0-30 μg/ml for Cilnidipine. The percentage recovery for Metoprolol and Cilnidipine a was found to be 100.29 and 100.25%, respectively. LOD and LOQ were found to be 0.03 μg/mL, 0.10 μg/mL for Metoprolol and 0.03 μg/mL, 0.09 μg/mL for Cilnidipine, respectively. No chromatographic interference from the tablet excipients was found. The stability-indicating nature of the proposed method was established by performing forced degradation, which provided degradation behaviour of Metoprolol and Cilnidipine under various conditions. The results of the studies showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which can be applied for the routine analysis of Metoprolol and Cilnidipine in tablet dosage forms.

Keywords: RP-HPLC, validation, metoprolol, cilnidipine, simultaneous and tablets.


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