Abstract

ENHANCEMENT OF DISSOLUTION RATE OF PIROXICAM USING CATION ION EXCHANGE RESIN-POLACRILIN POTASSIUM

Sruthi Jannu*, Raju V Dasu and Saikat Das, T.Ashwin Kumar, S.Sreenivasachary

ABSTRACT

Piroxicam is a nonsteroidal anti-inflammatory drug which is a poorly soluble, highly permeable drug (BCS class II) and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. The aim of this study was to enhance the dissolution of the drug Piroxicam. The tablets were prepared by direct compression method using different ratios of Polacrilin Potassium (cation ion exchange resin and disintegrating agent) by adding co-processed diluent Prosolv and hydrophilic lubricant Pruv. Investigated for the effect of drug/resin ratio (1:0.25, 1:0.5, 1:0.75 and 1:1 w/w) on the dissolution of drug. In vitro drug release studies were performed in dissolution medium of 0.1N HCl with volume of 900ml and paddle speed at 50 rpm. In vitro drug release studies of tablets containing 1:1 drug/resin ratio showed a significant drug release of more than 95% within 60 min compared with commercial tablets and pure drug. The tablets were evaluated for other general evaluation tests like weight variation, hardness, friability, disintegration time (DT) and were found to be acceptable according to standard limits of IP official pharmacopeias. Alteration of the drug/resin ratio allowed the drug dissolution to be significantly improved.

Keywords: piroxicam, polacrilin potassium, prosolv, direct compression.