Abstract

FORMULATION AND EVALUATION OF OSMOTIC CONTROLLED DRUG DELIVERY OF PROPANOLOL HYDROCHLORIDE BY SELF PORE FORMING MECHANISM

Sai Vishnu M.* and Surendranath B.

ABSTRACT

The Present work aimed to formulate and evaluate an osmotic drug delivery system of Propanolol Hydrochloride drug. Propanolol Hydrochloride is a class1 drug and hence rapidly absorbed and which shows quik shorter action hence it is formulated as Contolled Release formulation. Core tablet of Propanolol Hydrochloride was prepared using Sodium Acetate, Potassium chloride, Mannitol, PVPk30, MCC, Talc and Magnesium stearate. These tablets were prepared by wet granulation method according to composition given in table. All the ingrediants and drug were accurately weighed and mixed in motar with a pestle for 10minutes to get uniform mix. The drug blend was granulated with sufficient quantity of PVPk30 which was dissolved in Isopropyl alcohol. The granules were dried at 60º C in hot air oven for 6 hrs and pass through sieve no: 20. The dried granules were mixed with Magnesium Stearate and Talc for 3min. the blended powder was then compressed by using compression machine. The tablets of selected batch was coated with coating solution Cellulose Acetate, Castor oil and PEG400. The observed results revels that osmotic agents have significant effect on drug release up to 12 hrs in successful development of osmotic pump tablets containing Propanolol Hydrochloride by using Sodium Acetate, Potassium chloride and Mannitol as key exipients.

Keywords: Propanolol Hydrochloride, Sodium Acetate, Potassium chloride and Mannitol.