WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF IBUPROFEN AND FAMOTIDINE IN PHARMACEUTICAL DOSAGE FORM

T. Venkatakishore*, Dr. M. Prasadrao, B. Thulasi, K. Ambica, K. Mohan Satya Saikumar and G. Jaswanth

ABSTRACT

In this study, reversed phase high performance liquid chromatographic method have been developed and validated for the simultaneous determination of ibuprofen and famotidine in combined pharmaceutical formulation. In RP-HPLC method, optimization of chromatographic parameters was done. Optimization conditions was found to be 0.1% orthophosphoric acid (pH-3), acetonitrile in 50:50 v/v ratio as mobile phase at a flow rate of 0.8 mL/min. The peaks were well resolved with C18 column (46mm x 150mm , 5um) with a retention times 2.473 and 3.407 min for ibuprofen and famotidine respectively. UV detection was performed at 231 nm. The responses were linear (R2 > 0.9999) in the range of 80 – 400 μg/ml for ibuprofen and 2.6 – 13 μg/ml for famotidine. The % recovery for ibuprofen and famotidine was found to be 100.7 and 98.3 respectively. LOD and LOQ was found to be 0.121 μg/mL, 0.404 μg/mL for famotidine and 3.332 μg/mL, 11.1 μg/mL for ibuprofen respectively. No chromatographic interference from the tablet excipients was found. The results of the studies showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which can be applied for the routine analysis of ibuprofen and famotidine in tablet dosage forms.

Keywords: High performance liquid chromatography, validation, ibuprofen, famotidine and tablet dosage form.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More