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Abstract

CORONARY ARTERY BYPASS GRAFT SURGERY: BASELINE CHARACTERISTICS AND CLINICAL OUTCOMES IN DIABETIC AND NON-DIABETIC COHORT IN A TERTIARY REFFERAL CENTER

Celin Mary M.Pharm.,* Subramaniam Shanmugam M.Pharm., (PhD), Dr. Krishnan Swaminathan MD (UK), FRCP (UK)

ABSTRACT

Background: The aim of this study was to determine the baseline characteristics and clinical outcomes in diabetic and non-diabetic cohort undergoing coronary artery bypass graft (CABG) surgery. Method: A total of 100 patients with and without diabetes were enrolled in my prospective study. Among the 100 patients, 60 patients were diabetic and 40 were non-diabetic. The baseline characteristics and clinical outcomes were recorded between the diabetic and non-diabetic groups. Primary outcome was within discharge mortality and secondary outcomes were infections, arrhythmia, pulmonary embolism and stroke after CABG. Results: There was a significant difference observed between the two groups regarding random blood sugar (155.6±114.1 vs 73.6±64.1; P=<0.001), urea (34.4±24.3 vs 26.5±8.5; P=0.05), sodium (136.1±3.3 vs 138.1±2.3; P=0.001) and history of hypertension (58.33% vs 30%; P=0.005). But, there was no significant difference observed between the two groups regarding other baseline characteristics and CABG surgery characteristics. Also, there was no clinical outcomes observed. There were no within discharge mortality, no one month mortality, no wound or leg or hospital acquired infections, no arrhythmia, no stroke after CABG, no pulmonary embolism and no re-exploration for bleeding. Conclusion: Diabetes does not have a significant impact on adverse outcomes following CABG. However, long-term survival in diabetic patients remains significantly poorer than that of non-diabetics considering the burden of this disease.

Keywords: Coronary artery bypass graft, Diabetes mellitus, Coronary artery disease.


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