Abstract

GREEN SYNTHESIS OF SILVER NANOPARTICLES USING ZINGIBER OFFICINALE EXTRACT AND EVALUATION OF THEIR ANTIOXIDANT, ANTIMICROBIAL AND ANTI-INFLAMMATORY EFFECT

Saraswathi K., Vidhya J., Mohanapriya L. and P. Arumugam*

ABSTRACT

The aim of the study is to synthesize silver nanoparticles and to evaluate the antioxidant antimicrobial and anti-inflammatory potential using the Zingiber officinale extract (rhizome) of the family Zingiberaceae. The rhizome was used for the synthesis of silver nanoparticles by varying the time exposure of the reaction mixture to sunlight, UV and boiling temperature. The antioxidant property of the synthesized nanoparticles was effective in which the IC50 was determined to be 73.27μg/ml for metal chelating ability. The synthesized silver nanoparticles were characterized by UV-Visible spectroscopy and FTIR techniques. The antimicrobial activity was performed by Agar well diffusion assay against Staphylococcus aureus, Escherichia coli and Aspergillus niger. The result of the studies showed that the green synthesized silver nanoparticles possessed to have significant antioxidant, antimicrobial and anti-inflammatory properties. Thus, the green synthesized silver nanoparticles from Zingiber officinale can be used as a curative agent for targeted drug delivery to cure diseases.

Keywords: Nanoparticles, FTIR, Antioxidant activity, Anti-inflammatory activity.