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Dr. Sandeep Singh Tiwari*, Dr. Tribhuvan Pareek and Dr. Mamta Masram


Psoriasis is an autoimmune disease which is characterized by patches of abnormal skin these skin patches are typically red, itchy and scaly. It is common T- cell mediated immune disorder, characterized by circumscribed, red, thickened plaques with an overlaying silver white scale. Psoriasis is estimated to affect 2-4%, in age group 15-20yrs of the western world population. There are two key pathophysiological aspects to the abnormalities in psoriatic plaques. Psoriasis is originated by unknown cause but some new dietary style may be caused it, which are stress, cold water, dry skin, the solution, vaccination, beta blockers and lithium, upper respiratory infection, smoking, diet (gluten) and alcohol etc. Abnormal production of skin cells results and overabundance of skin cells results from the sequence of pathological events in psoriasis. Skin cells replaced every 3-5 days in psoriasis rather than the usual 28-30 days. These changes are believed to stem from the premature maturation of keratinocytes induced by an inflammatory cascade in the dermis involving dendrites cells, macrophages and T-cells. Epidermal skin tissue affected by psoriatic inflammation often has many CD8+ T-cells while a predominance of CD4+ T-cells makes up the inflammatory infiltrates of the dermal layer of skin.Psoriasis did not diagnosed by any specific blood test, so we are concluding its signs and symptoms along with its types. All types of psoriasis with symptoms are concluded to make a diagnostic tools of it. New methods in organization, planning and in co-operation at decision making level in health care might reduce time and cost for both patients and the public health care sector and help with efforts to reduce inequalities. It helps to understand psoriasis causes, pathology and symptoms, which helps to make its clear diagnosis and treatment.

Keywords: Keratinocytes, Trigger, interferon, interleukin.

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