Abstract

FORMULATION AND EVALUATION OF ALGINATE MICROBEADS OF PROPRANOLOL HYDROCHLORIDE BY USING NATURAL POLYMERS

Rajeshwar V.*

ABSTRACT

The aim of the present research was to formulate and evaluate alginate microbeads of propranolol hydrochloride by using ionotropic gelation technique. The prepared microbeads were evaluated for various parameters like percentage yield, particle size, flow property, entrapment efficiency, surface study, in-vitro drug release, X-Ray diffraction analysis, etc. It was found that all formulations showed improved flow behavior as compared to pure drug, it was observed that on increasing the polymer concentration of formulations the entrapment efficiency and particle size were increased. The surface morphology study by SEM indicated that microbeads were spherical with rough outer surface. There was no interaction between the drug and the polymers, as studied by FTIR study. In-vitro drug release study showed that on microsphere formulation its release was sustained and its release was affected by polymer concentration and it followed Higuchi model. Therefore, it can be concluded that Propranolol Hydrochloride loaded algino-chitosan microbeads can be formulated for sustained drug delivery of Propranolol Hydrochloride.

Keywords: Microbeads, propranolol hydrochloride, Ionotropic gelation technique, Algino-chitosan microbeads.