Abstract

PHARMACEUTICAL EVALUATION OF DIFFERENT BRANDS OF LEVOCETIRIZINE DIHYDROCHLORIDE TABLETS AVAILABLE IN LOCAL MARKET OF INDIA

P. Lakshmana Rao*, M. Prasada Rao, G. Anantha Lakshmi, B. Prameela, Md. Jabeen Sulthana, N. Anusha, K. Sai Kanaka Durga Sirisha, U. Tirupathi Rao

ABSTRACT

The quality of a pharmaceutical product is essential to ensure the safety of the patients. Different parameters of quality control of pharmaceutical products can guarantee the quality, bioavailability & optimal therapeutic activity. Therefore the aim of present study is a comparative quality control study on four different brands of conventional levocetirizine dihydrochloride tablets available in local market of India. Six Quality Control parameters like Weight variation test, Hardness test, Thickness, Friability, Disintegration test and Dissolution test were carried out specified by British & U.S Pharmacopoeias. To demonstrate the differences between the products, the difference (f1) and similarity (f2) data were analysed. Hardness value requirement was compiled by all brands. Disintegration times for all brands were within 60 min complying the B.P/ U.S.P Standards. All brands of levocetirizine dihydrochloride showed MT 80% drug release within 60 minutes. Weight variation of the tablets proved statistically that all the tablets were in accordance to the required limits that is NMT ± 5% deviation. The results showed that all the brands of levocetirizine dihydrochloride are available in Indian market meet the specification for Quality Control analysis.

Keywords: Levocetirizine Dihydrochloride, Weight variation, Disintegration, Dissolution, Quality control.