WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SUBACUTE INTRAVENOUS TOXICITY STUDY OF DISODIUM EDTA IN SWISS ALBINO MICE

Manu Chaudhary*, Parveen Kumar, Satish Kumar, Anand Kamal Sachdeva, Vinoth Kumar M.

ABSTRACT

The study was conducted to determine the sub acute toxicity of disodium EDTA upon slow intravenous injection in mice. Animals were divided into six groups and doses were administered for a period of 14 days in all the groups by slow intravenous injection. G1 was the vehicle control group. G2, G3 and G4 were the disodium EDTA treated (15, 30 & 60 mg/kg) group respectively. Groups G5 and G6 were the recovery groups observed for an additional period of 14 days after discontinuation of dosing. Clinical signs were recorded once daily in all the animals until their scheduled necropsy. Biochemical and hematological evaluations were performed on day 7 and 14 for animals of G1-G4 group and on day 28 for animals of G5 and G6 group. Gross pathology was performed and organs were collected for histopathology on terminal day. Results of the study suggested that there were no visible signs of toxicity in any group treated with disodium EDTA. Biochemical and hematological parameters were comparable to vehicle control groups in the main and recovery groups. Interim or terminal sacrifices did not reveal any significant pathological finding in the gross observations. Histological evaluations of disodium EDTA (60 mg/kg) group revealed an inflammatory lesions in the kidneys. However, in the recovery group did not show such lesions suggesting that the inflammatory lesions were transient and resolved upon discontinuation of treatment. It was concluded that repeated administration of disodium EDTA does not cause any observable toxicity.

Keywords: Disodium EDTA, Elores, Sub acute toxicity.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More