Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL N-{3-CHLORO-2-(SUBSTITUTEDPHENYL)-4-OXAZETIDIN-1-YL} ACETAMIDO SUCCINIMIDE DERIVATIVES

Pankaj Baboo* and S.K. Gupta

ABSTRACT

N-{3-Chloro-2-(substitutedphenyl)-4-oxazetidin-1-yl} acetamido succinimide(4a-4j) were synthesized by cyclization of substituted phenyl succinimido acetylhydrazide(3a-3j) and triethylamine by dissolving in dioxane, when chloroacetyl chloride was added dropwise. Substituted phenyl succinimido acetylhydrazide(3a-3j) were synthesized by condensation of various substituted aromatic aldehydes with N-succinimido acetylhydrazide(2), which was synthesized by equimolar mixture of ethyl N-succinimido acetate(1) and hydrazine hydrate by refluxing in presence of 1,4-dioxane. Ethyl N-succinimido acetate(1) was synthesized by equimolar condensation of succinimide and ethyl chloroacetate by refluxing in presence of anhydrous potassium carbonate. The formation of title compounds were established by physical and spectral studies. Further the synthesized compounds were subjected to microbiological screening.

Keywords: Azetidinone derivatives, oxazetidine derivatives, antimicrobial activity.