Abstract

EVALUATION OF HYPOGLYCEMIC ACTIVITY OF MURRAYA KOENIGII EXTRACTS IN ALLOXAN INDUCED DIABETIC RATS.

Shrinivas Sarje*, N B Ghiware, V N Gunjkar and S. M. Vadvalkar

ABSTRACT

The present study was aimed to evaluate the hypoglycemic activity of ethyl acetate and ethanolic extracts of Murraya koenigii in alloxan induced diabetic rats. Wistar rats of either sex were used for the study. The Wistar rats used for the experimental work were administered with alloxan (120 mg/kg) to induce diabetes. The rats having blood glucose levels above 200 mg/dl were selected and considered as diabetic rats. The diabetic rats were segregated into groups, with a minimum of at least 6 in each group and treated with Glimiperide 2 mg/kg, ethyl acetate and ethanolic extract of low dose 100 mg/kg and high dose 200 mg/kg separately for 21 days. Blood glucose level estimations were recorded on the 1st, 7th, 14th and 21 st day of the experiment using glucometer. Blood glucose levels increased in alloxan induced diabetic rats but the extracts of M. koenigii significantly reduced blood glucose levels.

Keywords: Alloxan, Murraya koenigii extracts, hypoglycemic activity, Glimiperide.