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Abstract

hsCRP AND FIBRINOGEN IN THE EARLY DIAGNOSIS OF ATHEROGENESIS IN MALE SMOKERS.

Dr. A. G. Thivyah Prabha* and Dr. J. N. Naidu

ABSTRACT

Cigarette smoking is one of the major health hazards of the world population as it is contributing to the cardiovascular diseases and to the increasing proportion of the sudden deaths. hsCRP and Fibrinogen are independent & signifigant markers of cardiovascular mortality. The aim of the study is to identify the earlier markers of atherogenesis in healthy adult male smokers for better risk prediction and screening purpose. 60 adult healthy men of age group 19-49 years were enrolled. 30 smokers & 30 non- smoker. Smokers were compared with the non-smokers by doing the blood tests which included blood glucose, lipidprofile, hsCRP & Fibrinogen. Smokers had significantly higher levels of total serum cholesterol [245.03±72.82 vs160.07±21.39 p<0.000], LDL levels[149.17±48.87vs.98.67±14.93p<0.000] and triglyceride levels [152.43± 52.40vs. 94.83±17.75p<0.000]. HDL levels were low in smokers. hsCRP & Fibrinogen levels were higher in smokers [6.8±3.04vs1.38±0.67p<0.00&644.20±231.38vs300.20± 49.91p<0.000] respectively. There is a positive correlation between hsCRP & Fibrinogen levels (r=0.882; p<0.000). There is a positive correlation between the duration of smoking and hsCRP& Fibrinogen levels [r=0.871, p<0.000 & r=0.917p<0.000]. This case control study shows significantly higher hsCRP& Fibrinogen levels in smokers in proportion to the duration & amount of cigarettes smoked pre day, as compared to the non-smokers. Thus hsCRP & Fibrinogen can be used as the bio markers of sub-clinical atherogenesis screening in healthy adult male smokers.

Keywords: Fibrinogen, highly Sensitive Crp [hscrp], Atherosclerosis, Smokers.


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